Fig. 3.

Hypoxia induced up-regulation of HIF-1α and PlGF in H1975 and H358 cells. a, b Cells are cultured under hypoxia (90% N₂, 5% CO₂ and 5% O₂) or normoxia (5% CO₂ and 95% air, control) for 12 h, 24 h, and 48 h. mRNA and protein levels of HIF-1α and PlGF in H1975 (a) and H358 (b) are compared between the hypoxic and normoxic conditions. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Control