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. 2021 Jan 6;28:1. doi: 10.1186/s40709-020-00131-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — HBP1 silence reverses the function of miR-203 on RASF growth and inflammation. RASFs were transfected with in-miR-NC, in-miR-203, in-miR-203 + si-NC, or in-miR-203 + si-HBP1. a, b Transfection efficiency was analyzed by using qRT-PCR or western blot. c, d The proliferation of RASFs was determined by colony formation assay and CCK-8 assay, respectively. e Flow cytometry was applied to detect the apoptosis of RASFs. f Western bolt analysis of Ki67, cleaved caspase3 and cleaved PARP expression in RASFs was carried out. g–j The level of inflammatory cytokines IL-6, IL-1β, IL-8 and TNF-α in RASFs was detected by ELISA assay. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001 (ANOVA)