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. 2021 Jan 6;22:6. doi: 10.1186/s12864-020-07186-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differential methylation at DNA methylation -regulating genes. a On a per-gene basis, the number of promoter CpGs that are differentially methylated by at least one cell type, out of the total number of promoter CpGs per gene. The y = x line is shown (blue), where genes with 100% of promoter CpGs are differentially methylated. The green line is a smoothed average. b Distribution of the percentage of promoter CpGs per gene that are differentially methylated. The dotted line represents an array-wide average. c DNA methylation at CpGs associated with DNMT1 for term placental samples (top). CpGs in CpG islands, imprinted regions, PMDs, and enhancers are indicated (middle). Associated UCSC transcripts and their genomic elements (promoter, 5′ UTR, exons, introns, 3’UTR) are displayed (bottom)