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. 2021 Jan 6;22:6. doi: 10.1186/s12864-020-07186-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — DNA methylation at partially methylated domains (PMDs), and imprinted differentially methylated regions (DMRs). a The percentage (y-axis) of CpGs in placental PMDs, falling into specific methylation intervals (0–20%, 20–40%, 40–60%, etc.) is shown for each cell type and trimester. b DNAm across specific regions on chromosome 21 (B) and 4 (c). PMDs are highlighted with a grey background. d Density plots (y-axis) of imprinted DMRs in term samples, divided into those that are imprinted in multiple tissues, (i.e. non-placental-specific; 1085 CpGs total; top) and placental-specific (981 CpGs total; bottom). The percentage of CpGs falling within 25%–75% is shown above each plot. e Cell-specific DNAm at the C19MC placental-specific imprinted DMR. This placental-specific imprint overlies a CpG island upstream of the miRNA cluster. f DNAm at placental-specific imprinted region for DCAF10