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. 2021 Jan 6;21:13. doi: 10.1186/s12935-020-01707-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — PPP2R2B was identified as a hub prognostic biomarker and associated with malignant progression of breast cancer. a Through Lasso penalized Cox regression analysis with 1000 iterations, a signature containing 4 genes was identified as an optimal signature with maximum 5 year AUC value. b The expression difference of 4 signature genes between breast normal tissues and TNBC tissues in TCGA. c Immunohistochemistry staining of PPP2R2B expression in breast normal tissues and TNBC tissues. d Quantitative real-time PCR analysis. e Kaplan‐Meier survival analysis of PPP2R2B in multiple TNBC datasets. ns Not significant, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001