Table 3.
Multiple linear regression showing the association between dietary fat and cg02263260 methylation in Taiwanese adults stratified by sex
| Variables | Women | Men | ||||||
|---|---|---|---|---|---|---|---|---|
| β | 95% CI | P-value | β | 95% CI | P-value | |||
| Dietary fat | ||||||||
| Low (reference) | – | – | – | – | – | – | – | – |
| Moderate | 0.00285 | − 0.00130 | 0.00700 | 0.1774 | − 0.00213 | − 0.00734 | 0.00307 | 0.4207 |
| High | 0.00597 | 0.00061 | 0.01133 | 0.0292 | − 0.00419 | − 0.01011 | 0.00172 | 0.1642 |
| P-trend 0.0283 | P-trend 0.1600 | |||||||
| Age | − 0.00002 | − 0.00022 | 0.00019 | 0.8763 | 0.00002 | − 0.00017 | 0.00022 | 0.8053 |
| BMI | − 0.00014 | − 0.00087 | 0.00058 | 0.6969 | − 0.00004 | − 0.00083 | 0.00075 | 0.9285 |
| Body fat | ||||||||
| Men < 25; women < 30 (reference) | – | – | – | – | – | – | – | – |
| Men ≥ 25; women ≥ 30 | 0.00247 | − 0.00246 | 0.00739 | 0.3256 | 0.00204 | − 0.00316 | 0.00724 | 0.4413 |
| Waist-hip ratio | ||||||||
| Men ≤ 0.9; women ≤ 0.85 (reference) | – | – | – | – | – | – | – | – |
| Men > 0.9; women > 0.85 | − 0.00139 | − 0.00549 | 0.00270 | 0.5041 | − 0.00173 | − 0.00616 | 0.00271 | 0.4451 |
| Exercise | ||||||||
| No (reference) | – | – | – | – | – | – | – | – |
| Yes | 0.00332 | − 0.00053 | 0.00716 | 0.0908 | − 0.00095 | − 0.00502 | 0.00311 | 0.6446 |
| Cigarette smoking | ||||||||
| Never (reference) | – | – | – | – | – | – | – | – |
| Former | − 0.00148 | − 0.01081 | 0.00784 | 0.7545 | 0.00054 | − 0.00411 | 0.00520 | 0.8192 |
| Current | − 0.00751 | − 0.01841 | 0.00338 | 0.1759 | − 0.00096 | − 0.00615 | 0.00424 | 0.7171 |
| Alcohol drinking | ||||||||
| Never (reference) | – | – | – | – | – | – | – | – |
| Former | 0.00349 | − 0.01757 | 0.02455 | 0.7446 | − 0.00019 | − 0.00911 | 0.00873 | 0.9667 |
| Current | 0.00571 | − 0.01071 | 0.02213 | 0.4947 | 0.00043 | − 0.00537 | 0.00623 | 0.8842 |
| Coffee consumption | ||||||||
| No (reference) | – | – | – | – | – | – | – | – |
| Yes | − 0.00125 | − 0.00496 | 0.00247 | 0.5094 | 0.00055 | − 0.00339 | 0.00450 | 0.7828 |
| Tea consumption | ||||||||
| No (reference) | – | – | – | – | – | – | – | – |
| Yes | 0.00350 | − 0.00032 | 0.00731 | 0.0721 | − 0.00092 | − 0.00476 | 0.00293 | 0.6393 |
| Vegetarian diet | ||||||||
| No (reference) | – | – | – | – | – | – | – | – |
| Yes | 0.00242 | − 0.00531 | 0.01015 | 0.5393 | − 0.00250 | − 0.01412 | 0.00913 | 0.6732 |
| HDL-C | − 0.00017 | − 0.00041 | 0.00007 | 0.1718 | 0.00003 | − 0.00025 | 0.00032 | 0.8121 |
| LDL-C | − 0.00003 | − 0.00022 | 0.00017 | 0.7916 | − 0.00002 | − 0.00024 | 0.00020 | 0.8830 |
| TG | − 0.00001 | − 0.00005 | 0.00002 | 0.3538 | 0.00000 | − 0.00005 | 0.00004 | 0.8367 |
| TC | 0.00000 | − 0.00019 | 0.00019 | 0.9953 | 0.00005 | − 0.00017 | 0.00027 | 0.6497 |
Sex*Dietary fat: P-value = 0.0145
BMI body mass index, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, TC total cholesterol