Table 3.

Summary of reported adverse side effects seen during drug administration of radical, preventive and presumptive treatment

Adverse side effects	No. observed	No. side effects (%)
(1) Preventive treatment: 600 mg piperaquine phosphate once a month [46]
Mild side effects: dizziness, nausea and cheek numbing [46].	238	103(43.3%)
(2) Radical treatment: 90 mg primaquine for 4 days [49]
Side effect: haemolysis [49].	2,529	8(0.32%)
(3) Radical cure: 150 mg primaquine for 5 days [50].
Mild side effects: dizziness, nausea and headache [50]	853	114(13.4%)
(4) Radical treatment: 150 mg primaquine for 5 days plus 100 mg pyrimethamine for 2 days [50]
Mild side effect: dizziness, nausea and headache [50]	1,381	264(19.1%)
(5) Radical treatment: 180 mg primaquine for 8 days plus 100 mg pyrimethamine for 2 days [51, 55]
Serious side effects: dizziness, nausea, headache, shivering, hyperspasmia and eventually death [51]	1	1
Other side effects: varying levels of dizziness, nausea and headache [55]	857	174(20.3%)
(6) Accident: mistakenly taking 2500 mg pyrimethamine as a single dose [53]
Serious side effects: hematocyanosis and eventual death [53]	1	1
(7) Radical treatment: primaquine 22.5 mg daily × 8 days and pyrimethamine 50 mg daily × 2 days [23]
Haematuria, weakness, fever, appetite loss, abdominal pain/discomfort, dizziness and headache, bruising, epistaxis [23]	254,910	9 (0.0035%)
(8) Radical treatment: primaquine 30 mg daily × 4 days and pyrimethamine 50 mg daily × 2 days [23]
Jaundice, fever, loss of appetite, weakness, dizziness, haematuria, dark coloured urine, abdominal pain, cyanosis, and headache [23]	444,589	40 (0.009%)