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. 2021 Jan 6;23:4. doi: 10.1186/s13075-020-02371-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Associations between HBM and incident and progressive OA and change in OA sub-phenotypes. Points for continuous outcomes represent the difference in mean outcome between individuals with and without HBM (for example, a beta of 1 for change in osteophyte score would represent a 1-point greater increase in summed osteophyte score, which is the equivalent of the appearance of one additional osteophyte over 8 years or the increase in the size of an osteophyte already present). Points for binary outcomes represent the odds ratio for individuals with HBM compared to their relatives with normal BMD. Model 1: unadjusted; model 2: adjusted for age, sex and follow-up time (plus baseline score for continuous outcomes); model 3: adjusted for age, sex, follow-up time, height and TBFM (plus baseline score for continuous outcomes). N_{incident OA} = 248; N_{continuous outcomes} = 263. Abbreviation: JSN joint space narrowing