Table 2.

Prediction of inotropic and respiratory support and thrombocytopenia

	Total population (n = 480)	Interleukin-6	Procalcitonin	C-reactive protein
Inotropic support	N = 67 cases (14%)
AUC		0.71	0.79	0.65
95% CI		0.63–0.80	0.63–0.80	0.56–0.73
Exploratory cutoff		118 pg/mL	1.03 ng/mL	6.3 mg/L
Sensitivity		63.1%	79.6%	58.9%
Specificity		77.8%	71.1%	65.7%
Thrombocytopenia	N = 79 cases (16.5%)
AUC		0.77	0.83	0.79
95% CI		0.67–0.88	0.72–0.93	0.69–0.89
Exploratory cutoff		391 pg/mL	1.89 ng/mL	11.0 mg/L
Sensitivity		60.0%	79.2%	80.0%
Specificity		88.1%	82.3%	72.6%
	Total population (n = 401)
Respiratory support	N = 68 cases (17%)
AUC		0.67	0.72	0.59
95% CI		0.60–0.74	0.65–0.80	0.51–0.67
Exploratory cutoff		201 pg/mL	1.6 ng/mL	27 mg/L
Sensitivity		39.7%	45.3%	23.9%
Specificity		85.6%	85.8%	86.9%

Data represent AUC values with their respective 95% confidence intervals, exploratory cutoff points with sensitivity and specificity for each biomarker