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. 2021 Jan 6;40:11. doi: 10.1186/s13046-020-01798-2

Fig. 3.

Fig. 3

NcRNAs regulate AS through cis-acting elements. a One example of a cis-NAT: the lncRNA Saf binds specifically to the Ex 6 (exon 6) region of the Fas pre-mRNA and recruits SPF45, resulting in the expression of the sFas isoform, which consequently inhibits apoptosis. b One example of a trans-NAT: the lncRNA BC200 binds to Bcl-x pre-mRNA Ex 3 (exon 3) and recruits hnRNPA1/B2 to form the BC200-Bcl-x-hnRNPA2/B1 complex. This complex contributes to Bcl-xL expression and apoptosis resistance in breast tumor cells