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. 2021 Jan 6;22:2. doi: 10.1186/s12865-020-00394-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Itgb2^mut mice did not develop infection induced goblet cell hyperplasia in response to infection with T. muris and had fewer MUC-2 expressing cells in the colon than littermate controls in response to infection. Itgb2^mut and WT littermate controls mice were infected with 200 embryonated T. muris eggs and harvested at Day 0 (D0) (a, b), D5, and D19 (c, d) post-infection. Representative images of colons taken from one of two experiments that were assessed by PAS staining for the quantification of goblet cells (a-d) or Muc2 to identify mucin-2 expressing cells (e-h). Images were analysed using Image J software and (i) the number of goblet cells, (j) the number of Muc-2 expressing cells, and (k) the ratio of goblet to epithelial cells were calculated as the mean of 20 measurements /tissue section, n = 4–8/time point. *(P < 0.05), (**p < 0.01)