Table 4.

AUCs, ideal cut-offs, sensitivity, and specificity of surrogate markers for IR and insulin secretion for identifying MetS in the ROC analysis

Variable	AUC (95% CI)	P	Cut-off value	Sensitivity	Specificity	Youden index
HOMA-IR	0.851 (0.784–0.904)	0.001	≥ 2.86	86.67	70.67	0.5733
HOMA2-IR	0.787 (0.712–0.849)	0.001	≥ 1.69	80.01	65.33	0.4533
HOMA-AD	0.846 (0.778–0.899)	0.001	≥ 6.26	68.14	85.33	0.5333
HOMA-TG	0.755 (0.678–0.822)	0.001	≥ 0.72	53.33	81.35	0.3467
TyG index	0.836 (0.767–0.891)	0.001	≥ 9.88	76.00	88.00	0.6400
FIGR	0.548 (0.465–0.630)	0.335	≥ 2.41	85.33	46.67	0.3200
FIRI	0.768 (0.669–0.850)	0.001	≥ 2.96	83.67	70.47	0.4414
HOMA-1%S	0.850 (0.783–0.903)	0.001	≤ 28.2	82.74	77.33	0.5731
HOMA-2%S	0.779 (0.704–0.843)	0.001	≤ 53.9	69.33	74.67	0.4400
QUICKI	0.844 (0.776–0.898)	0.001	≤ 0.32	93.33	61.33	0.5467
Bennet index	0.795 (0.721–0.856)	0.001	≤ 1.2	89.30	74.62	0.4534
McAuley index	0.815 (0.743–0.874)	0.001	≤ 6.05	78.76	92.12	0.4937
Raynaud index	0.742 (0.664–0.810)	0.001	≤ 3.10	76.01	62.67	0.3867
1/Insulin	0.735 (0.657–0.804)	0.001	≤ 0.08	86.67	50.15	0.3733
GI ratio	0.547 (0.464–0.629)	0.343	≤ 7.45	85.33	55.81	0.2928
FISI	0.797 (0.724–0.858)	0.001	≤ 6.96	83.67	70.37	0.4414
SPISE	0.822 (0.751–0.880)	0.001	≤ 3.79	73.47	90.70	0.5067
HOMA-1%B	0.784 (0.680–0.875)	0.001	≤ 94.74	71.43	74.42	0.4585
HOMA-2%B	0.842 (0.773–0.896)	0.001	≤ 87.12	93.62	76.74	0.6800

Cut-off values correspond to the highest Youden index.

AUC, area under the curve; IR, insulin resistance; MetS, metabolic syndrome; ROC, receiver operating characteristic; HOMA, homeostatic model assessment; AD, adiponectin; TG, triglycerides; TyG, triglyceride-glucose; FIGR, fasting insulin to glucose ratio; FIRI, fasting insulin resistance; %S, insulin sensitivity; QUICKI, quantitative insulin sensitivity check index; 1/Insulin, reciprocal insulin; GI, glucose to insulin; FISI, fasting insulin sensitivity index; SPISE, single-point insulin sensitivity estimator; %B, beta-cell function.