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. 2020 Dec 28;26(48):7664–7678. doi: 10.3748/wjg.v26.i48.7664

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Positron emission tomography imaging study on a 75-year-old man with hepatocellular carcinoma. ¹⁸F-Fludeoxyglucose (FDG) and ⁶⁸Ga-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography imaging was performed. A: Maximal intensity projection, ⁶⁸Ga-PSMA revealed focal uptake [bold orange arrow, standardized uptake value (SUV)max: 7.6; black arrow, SUVmax: 5.7]; B: Maximal intensity projection, ¹⁸F-FDG revealed focal uptake (bold white arrow, SUVmax: 4.6), no uptake in right lesion (white arrow); C: Gross section displayed a nodule histologically classified as hepatocellular carcinoma; D: Strong PSMA expression (400 ×, immunohistochemistry, scale bar = 100 μm) was shown in the tumor-associated vascular; E and G: Transaxial fused, ⁶⁸Ga-PSMA revealed focal uptake (bold black arrow, SUVmax: 7.6; black arrow, SUVmax: 5.7); F and H: Transaxial fused, ¹⁸F-FDG revealed focal uptake (bold white arrow, SUVmax: 4.6), no uptake in right lesion (white arrow).