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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Nat Med. 2020 Jul 13;26(9):1452–1458. doi: 10.1038/s41591-020-0964-7

Extended Data Fig. 6. CCR2 inhibition mitigates MI-induced accelerated tumor growth.

Extended Data Fig. 6

(a) Outline of CCR2 inhibition study in mice implanted with E0771 tumor cells and exposed to MI or sham surgery. CCR2 inhibitor (CCR2i) was administered starting at 7 days after MI or sham surgery. (b) Tumor volume over the course of the study (left) and at sacrifice (day 20 day) (right) in mice exposed to MI (n=5 CCR2 inhibitor, n=7 DMSO control) or sham surgery (n=8 CCR2 inhibitor, n=7 DMSO control). Two independent experiments were conducted (a-c). P values were calculated using a repeated measures analysis of variance (ANOVA) with Bonferroni’s multiple comparisons test (b) or one way ANOVA (c).