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. 2021 Jan 6;9(1):e001858. doi: 10.1136/bmjdrc-2020-001858

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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On unbiased univariate analysis of 798 patients admitted with COVID-19, the Clinical Frailty Scale (CFS) score was a significant independent predictor of poor outcomes, with a marginal effect size of 3% for every increase in score between 1 and 9 (see table 2). We stratified the marginal effect by age bands. There was a trend (A) for the marginal effect of the CFS score on the primary outcome to be greater in the older population. Similarly, there was a trend for the independent marginal effect of platelet count on the primary outcome to increase with age (B), but there was no interaction with the marginal effect size of platelet count on outcomes as stratified by the use of antiplatelet drugs (data not shown).