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. 2020 Dec 17;23(2):147. doi: 10.3892/mmr.2020.11786

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Liraglutide improves the viability and autophagy induced by PA via FoxO1. (A) A Cell Counting Kit-8 assay was used to analyze the viability of INS-1 cells in each group. Data were analyzed by paired t-test and are presented as the mean ± SD (n=3). *P<0.05 vs. GLP-1 + siCON group; ^#P<0.05 vs. PA + siCON group. (B) Western blotting was used to detect the expression levels of FoxO1 and LC3 in each group. FoxO1, Forkhead box O1; LC3, microtubule-associated protein 1 light chain3; CON, control; PA, palmitate; GLP-1, glucagon-like peptide-1; si, small interfering RNA.