Table 1.
Biochemical reference intervals for healthy bare-nosed wombats (Vombatus ursinus and southern hairy-nosed wombats(Lasiorhinus latifrons) obtained from the literature together with the mean, minimum and maximum values obtained from healthy bare-nosed wombats at all time points during the 25 mg/kg and 85 mg/kg trials
| Biochemical parameter | Reference intervals | 25 mg/kg trial (n = 5) | 85 mg/kg trial (n = 2) | |||
|---|---|---|---|---|---|---|
| BNW | SHNW | Mean | (Min–max) | Mean | (Min–max) | |
| Sodium (mmol/l) | 128.8–154.8 | 132.0–143.0 | 136.0a | 129.0–146.0 | 136.9 | 135.0–140.0 |
| Potassium (mmol/l) | 1.4–17.1 | 4.1–10.8 | 5.4 | 4.0–8.4 | 5.4a | 4.6–7.1 |
| Chloride (mmol/l) | 81.0–106.2 | 87.7–101.9 | 93.4 | 82.0–102.0 | 93.4 | 88.0–97.0 |
| Bi-carbonate (mmol/l) | 24.9–43.4 | 31.0–54.6 | 34.5a | 27.0–47.0 | 32.2a | 29.0–37.0 |
| Sodium:potassium ratio | 18.6–32.1 | 9.4–29.4 | 25.4a | 16.4–35.3 | 25.7 | 19.0–29.8 |
| Anion gap (mmol/l) | 9.5–20.9 | – | 13.6a | 2.0–23.2 | 16.7 | 12.5–19.6 |
| Urea (mmol/l) | 0.6–19.3 | 3.4–16.8 | 10.4 | 5.7–17.9 | 7.5 | 5.4–10.5 |
| Creatinine (μmol/l) | 34.0 – 278.8 | 72.4–307.6 | 80.0 | 40.0–130.0 | 91.0a | 50.0–140.0 |
| Phosphorous (mmol/l) | 0.5–3.0 | 0.5–3.3 | 1.8 | 0.9–4.5 | 2.5a | 1.8–5.1 |
| Calcium (mmol/l) | 1.9–3.4 | 2.3–2.7 | 2.6 | 2.3–3.5 | 2.5 | 2.3–2.7 |
| Total protein (g/l) | 46.1–86.5 | 54.5–72.5 | 62.2 | 57.0–70.0 | 58.8 | 54.0–64.0 |
| Albumin (g/l) | 20.2–38.2 | 22.0–43.0 | 34a | 24.0–39.0 | 35.1 | 31.0–40.0 |
| Globulin (g/lL) | 16.9–53.6 | 17.0–37.8 | 28.2a | 20.0–37.0 | 23.7 | 22.0–27.0 |
| Albumin: globulin ratio | 0.0–8.7 | 0.8–2.0 | 1.2a | 0.7–1.9 | 1.5 | 1.2–1.7 |
| Alkaline phosphatase (U/l) | 0.0–1364.0 | 0.0–497.4 | 507.3a | 242.0–884.0 | 920.7a | 518.0–1339.0 |
| Aspartate animotransferase (U/l) | 0.0–186.8 | 4.0–73.8 | 60 | 42.0–111.0 | 59.8 | 41.0–100.0 |
| Alanine aminotransferase (U/l) | 0.0–162.6 | 0.4–93.0 | 35.2a | 22.0–63.0 | 26.0 | 19.0–35.0 |
| Creatine kinase (U/l) | 0.0–5032.4 | – | 200.5 | 14.0–1593.0 | 463.3 | 26.0–2791.0 |
| Cholesterol (mmol/l) | 0.75–4.2 | 1.8–4.2 | 1.3 | 0.8–2.1 | 2.2a | 1.4–2.9 |
Parameters that deviated from reference intervals for bare-nosed or southern-hairy nosed wombats are highlighted in italics
BNW, Bare-nosed wombat; min–max, minimum–maximum values; SHNW, southern hairy-nosed wombat
aSignificant change observed over time-post fluralaner administration