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Cox regression results of HHT manifestations and gene mutations
| Characteristic | HR | 95% CI | p value |
|---|---|---|---|
| Brain VM | 0.76 | (0.35, 1.66) | 0.494 |
| Pulmonary AVM | 1.12 | (0.64, 1.96) | 0.681 |
| Symptomatic Liver VM | 2.10 | (1.15, 3.84) | 0.015 |
| GI bleeding | 2.63 | (1.46, 4.74) | 0.001 |
| Anemia | 2.93 | (1.37, 6.26) | 0.006 |
| ACVRL1 (vs. ENG) | 1.54 | (0.70, 3.38) | 0.286 |
| SMAD4 (vs. ACVRL1/ENG) | 18.36 | (5.60, 60.20) | < 0.001 |
Characteristics were tested individually, while adjusting for age, sex, and smoking status
