Table 3.

Biomarker research of circRNAs in cancers

Cancer type	CircRNA	Existence	Expression	Clinical Value	Ref.
Gastric cancer	hsa_circRNA_102958	Tissue	Up	Diagnosis	[105]
	hsa_circ_0074362		Down		[106]
	hsa_circ_0003159		Down		[107]
	hsa_circ_0000190	Tissue and plasma	Down		[108]
	circPSMC3		Down		[78]
	circ-KIAA1244		Down		[109]
	hsa_circ_0000520		Down		[110]
	circ-DCAF6	Tissue	Up	Prognosis	[111]
	circPDSS1		Up		[112]
	circ-DONSON		Up		[76]
	circLMTK2		Down		[112]
	circLARP4		Down		[113]
	hsa_circ_0001895		Down	Diagnosis and prognosis	[114]
	hsa_circ_0065149	Plasma exosome	Down		[115]
Colorectal cancer	circRNA_0001178	Tissue	Up	Diagnosis	[93]
	circRNA_0000826		Up		[93]
	circVAPA	Tissue and plasma	Up		[116]
	hsa_circ_0004585	Tissue and peripheral blood	Up		[117]
	circDDX17	Tissue	Down		[118]
	circRNA0003906		Down		[119]
	hsa_circ_001988		Down		[120]
	circ-ITGA7		Down		[90]
	circHIPK3		Up	Prognosis	[89]
	circCCDC66		Up		[45]
	circ_0026344		Down		[121]
Lung cancer	circRNA_102231	Tissue	Up	Diagnosis	[122]
	hsa_circ_0014130		Up		[123]
	hsa_circ_0001946		Down		[124]
	hsa_circ_0033155		Down		[125]
	circ_0067934		Up	Prognosis	[126]
	hsa_circ_0000792		Up		[127]
	hsa_circRNA_103809		Up		[128]
	circARHGAP10		Up		[83]
	circTP63		Up		[84]
	circRNA_100876		Up		[129]
Hepatoma	circFBLIM1	Tissue	Up	Diagnosis	[63]
	circRNA_100338		Up		[54]
	hsa_circ_0005075		Up		[61]
	hsa_circ_0091579		Up	Diagnosis and prognosis	[130]
	hsa_circ_0128298		Up		[131]
	hsa_circ_0078602		Down		[132]
	circ-0051443	Plasma exosomes and tissues	Down	Diagnosis	[71]
Breast cancer	circGFRA1	Tissue	Up	Diagnosis	[133]
	hsa_circ_0072309		Up	Prognosis	[134]
	circKIF4A		Up		[135]
	CircEPSTI1		Up		[72]
	circ-ITCH		Down		[136]
	circKDM4C		Down		[137]
Bladder cancer	hsa_circ_0018069	Tissue	Down	Diagnosis	[138]
	circPRMT5	Tissue serum and urine exosome	Up	Prognosis	[139]
	circLPAR1	Tissue	Down		[140]
	circMTO1		Down		[141]
	hsa_circ_0000285	Tissue and serum	Down		[142]
Osteosarcoma	circPVT1	Tissue and serum	Up	Diagnosis	[143]
	circ_HIPK3	Tissue	Down		[144]
	hsa_circ_0002052		Down	Prognosis	[145]
	hsa_circ_0081001	Tissue and serum	Up	Diagnosis and prognosis	[146]
Esophageal squamous cell carcinoma	hsa_circ_0006168	Tissue	Up	Diagnosis	[147]
	cicrRNA_100876		Up	Prognosis	[100]
	hsa_circ_0067934		Up	PROGNOSIS	[148]
Leukemia	hsa_circ_0004277	Tissue	Down	Diagnosis	[149]
	circ-CBFB		Up	Diagnosis and prognosis	[150]
Glioma	cir-ITCH	Tissue	Down	Diagnosis and Prognosis	[151]
	circCPA4	Tissue	Up	Prognosis	[91]
Nasopharyngeal carcinoma	circRNA_0000285	Tissue and serum	Up	Prognosis	[152]
Oral squamous cell carcinoma	hsa_circ_001242	Tissue	Down	Diagnosis	[153]
Cholangiocarcinoma	Cdr1as	Tissue	Up	Prognosis	[154]
Pancreatic cancer	circ-LDLRAD3	Tissue and plasma	Up	Diagnosis	[155]
Papillary thyroid carcinoma	hsa_circ_0137287	Tissue	Down	Diagnosis	[156]
Cervical cancer	circRNA8924	Tissue	Up	Diagnosis	[157]