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. 2021 Jan 6;21:12. doi: 10.1186/s12906-020-03180-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Renal function impairment and pathological lesions were alleviated by SK on the 14th day of treatment. a Levels of Cys-C (n = 6); b levels of BUN (n = 6); c levels of SCr (n = 6); d representative images of histopathological manifestations in obstructed kidneys detected on the 14th day (HE staining, 200×). The data are presented as the mean ± SEM; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus the sham group; *P < 0.05, **P < 0.01, ***P < 0.001 versus the UUO group (A = sham group, B = UUO group, C = ARB group, D = low-dose SK group, E = moderate-dose SK group, F = high-dose SK group)