Figure 2. Nodal regulators of cardiac fibroblast cell state.

Extracellular paracrine and microenvironmental signals including TGFβ Angiotensin II, stretch, and matrix stiffness are transduced through. Following transcription, myofibroblast transcripts and hence the proteome are further regulated by RNA binding proteins like MBNL1. Solid lines denote connections directly supported by evidence in the cardiac fibroblasts, whereas dashed lines are based on data from other fibroblast types.