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. 2021 Jan 6;19:9. doi: 10.1186/s12951-020-00749-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Anti-tumor effect of IGM in vivo. a Time-dependent tumor growth curves in 4T1 tumor after various treatments with intravenous injection (n = 6, **P<0.01, IGM + NIR vs. other groups). b Tumor weight at the end of treatment (n = 6, **P<0.01, IGM + NIR vs. other groups). c H&E, TUNEL, and HSP-90 staining of tumors at day 3 after various treatments (Scale bar = 100 μm). d Body weight of mice in different groups during therapy period. Data are expressed as mean ± SD (n = 6)