Table 2.
Distribution of IL-23A, IL-12B and IL-17A gene polymorphisms in healthy controls, pregnant woman and preeclampsia patients
| Genotype/Allele | HW (n = 147) | PW (n = 102) | PE (n = 115) | PW vs PE (P value, OR, 95% CI) |
|---|---|---|---|---|
| IL-23A (rs11171806) | ||||
| GG | 135 (92) | 95 (93) | 92 (80) | 1, ref |
| GA | 11 (7) | 7 (7) | 22 (19) | 0.008, 3.24, 1.31 to 8.53 |
| AA | 1 (1) | 0 | 1 (1) | – |
| G | 281 (96) | 197 (97) | 206 (90) | 1, ref |
| A | 13 (4) | 7 (3) | 24 (10) | 0.004, 3.27, 1.44 to 8.18 |
| IL-12B (rs3212227) | ||||
| AA | 125 (85) | 89 (87) | 93 (81) | 1, ref |
| AC | 21 (14) | 12 (12) | 20 (17) | 0.25, 1.59, 0.75 to 3.47 |
| CC | 1 (1) | 1 (1) | 2 (2) | 1, 1.91, 0.21 to 28.01 |
| A | 271 (92) | 190 (93) | 206 (90) | 1, ref |
| C | 23 (8) | 14 (7) | 24 (10) | |
| IL-17A (rs2275913) | ||||
| GG | 54 (37) | 39 (38) | 24 (21) | 1, ref |
| GA | 62 (42) | 44 (43) | 65 (56) | 0.007, 2.40, 1.29 to 4.47 |
| AA | 31 (21) | 19 (19) | 26 (23) | 1, 0.96, 0.47 to 1.96 |
| G | 170 (58) | 122 (60) | 113 (49) | 1, ref |
| A | 124 (42) | 82 (40) | 117 (51) | 0.02, 1.54, 1.05 to 2.25 |
| IL-17A (rs1974226) | ||||
| CC | 129 (88) | 87 (85) | 102 (89) | 1, ref |
| CT | 16 (11) | 13 (13) | 13 (11) | 0.83, 0.85, 0.37 to 1.94 |
| TT | 2 (1) | 2 (2) | 0 | – |
| C | 274 (93) | 187 (92) | 217 (94) | 1, ref |
| T | 20 (7) | 17 (8) | 13 (6) | 0.34, 0.65, 0.32 to 1.36 |
| IL-17A (rs3748067) | ||||
| CC | 119 (81) | 82 (80) | 91 (79) | 1, ref |
| CT | 26 (18) | 20 (20) | 24 (21) | 0.86, 1.08, 0.56 to 2.08 |
| TT | 2 (1) | 0 | 0 | – |
| C | 264 (90) | 184 (90) | 206 (90) | 1, ref |
| T | 30 (10) | 20 (10) | 24 (10) | 0.87, 1.07, 0.58 to 2.04 |
Data are presented in number (%)
HW Healthy non-pregnant woman, PW Pregnant woman, PE Preeclampsia patients, OR Odds ratio, CI Confidence interval