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P-gp, MRP2, and CYP3A4 expression in the intestinal mucosa of normal and PH rats. a RT-PCR results showing cyp3A1, MDR1 (mdr1a, mdr1b), and mrp2 mRNA expression in the intestines of normal (Group N) and PH (Group PH) rats. b Western blot showing CYP3A4, P-gp, and MRP2 protein expression in rat intestine. c Immunohistochemical detection of CYP3A4, P-gp, and MRP2 in rat intestine (100x magnification). Results are expressed as mean ± S.D. (n = 3). *p < 0.05, Group PH versus Group N
