Table 2.
ID | Phenotype | Sex | Age (yrs) | First sensation (mL) | Maximum cystometric capacity (mL) | Bladder pressure study | Pdet@Qmax (cm H2O) | Qmax (mL/s) | EMG finding | Vesical wall | Impression |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | AMN | F | 63.6 | "Very early in filling phase" | Normal | – | 14 | 10 | – | smooth | Neurogenic hypocontractile detrusor |
2 | AMN | F | 80.2 | 112 | 263 | Phasic detrusor contractions | 56 | 11 | Synergy | Smooth | NDO |
3 | AMN | M | 57.4 | 155 | 155 | No phasic detrusor contractions | 13 | 5 | Synergy | Markedly trabeculated | NDO, impaired contractility |
4Aa | CALD post-HSCT | M | 21.9 | 195 | 411 | No phasic detrusor contractions | 42 | 19 | Synergy | Smooth | Normal |
4Ba | CALD post-HSCT | M | 23.2 | 62 | 139 | Phasic detrusor contractions | 26 | 11 | Sphincter dyssynergia | – | NTDO with DSD |
5 | AMN, self-halted CALD | M | 28.2 | 32 | 216 | Phasic detrusor contractions | 66 | 9 | Synergy | Smooth | NDO, BOO, multi-phasic micturition |
6 | AMN, self-halted CALD | M | 36.3 | 30–45 | 43 | Terminal detrusor overactivity | 62 | 3 | Sphincter dyssynergia | Moderately trabeculated | NTDO with DSD |
7 | AMN, self-halted CALD | M | 20.9 | 262 | 348 | No phasic detrusor contractions | 47 | 15 | Synergy | Smooth | NTDO, neurogenic delay in sensory arm |
8 | AMN | F | 47.2 | 130 | 431 | Phasic detrusor contractions | 8 | 3 | Synergy | Smooth | NDO |
9 | AMN | F | 47.2 | 132 | 545 | Phasic detrusor contractions | 20 | 10 | Synergy | Smooth | NDO, impaired contractility |
10 | AMN | M | 46.9 | 78 | 293 | Phasic detrusor contractions | 56 | 11 | Synergy | Smooth | severe NDO |
11 | AMN, self-halted CALD | M | 34.8 | 286 | 359 | Phasic detrusor contractions | 51 | 11 | Synergy | Smooth | NDO |
Summary of urodynamic patient data collected at Massachusetts General Hospital, describing a diverse array of neurogenic bladder presentations
aPatient 4 had urodynamic studies performed at two timepoints
BOO, bladder outlet obstruction; DSD, detrusor sphincter dyssynergia; HSCT, hematopoietic stem cell transplant; NDO, neurogenic detrusor overactivity; NTDO, neurogenic terminal detrusor overactivity; Pdet, detrusor pressure; Qmax, peak urinary flow rate