Table 2.
Neuroimaging findings and pathological data
| Patients | MRI | EEG/MEG | FDG-PETa | [11C]DPA713PET increased uptake | sedation during DPA713PET | TSPO, SNP | Surgeryb |
|---|---|---|---|---|---|---|---|
| 1 | Normal | L-F | Normal | No specific uptake | – | HAB | Focal ECoG (I) |
| 2 | R-O | R-TO | R-TO | R-O, R > L-T | – | HAB | Focal resection(I) |
| 3 | R-T | R-T | R-T | R-T | – | HAB | Focal resection(I) |
| 4 | atrophy | Bi-F | R-T | R-cingulate | PTB, LMP | HAB | – |
| 5 | R-T | R-T | Bi-T | R-T | – | HAB | Focal resection (I) |
| 6 | Multi (L-T) | L-CTO | N.D | L-TPO | THP,MDZ | HAB | P-quadrantectomy (III) |
| 7 | Multi | Bi-FTO | N.D | Bi-F | THP,MDZ | HAB | – |
| 8 | Normal | R-F, L-F | Normal | No specific uptake | TRF, THP | HAB | Callosotomy (IV) |
| 9 | R-FTP | R-FC | R-TP | R-FTP | MDZ,THP,PTZ | HAB | – |
| 10 | L-F, R-T | L-F | Bi-F | L-F | THP,PTZ | MAB | Focal resection (II) |
| 11 | O (R>L) | L-O | Bi-OPT | Bi-O | – | HAB | Focal resection (I→III) |
| 12 | R-F | R-C | R-FT | R-F | – | HAB | – |
| 13 | R-F | L-F | R-FT | R-F | – | HAB | – |
| 14 | Normal | Bi-F | Normal | L-F | – | HAB | – |
| 15 | L-T | Diffuse | L-T | L-T | THP | HAB | Focal resection (II) |
| 16 | Normal | L-F, R-FT | Normal | No specific uptake | THP, MDZ | HAB | – |
| 17 | MT | R-T | R-F, L-P, T | R-insula, O | DZP | HAB | Focal resection (III) |
| 18 | MT | L-T, P, O | N.D | R-F,L-F | THP,MDZ,PTZ | HAB | – |
| 19 | Normal | CSWS (R>L) | N.D | Bi-P, R-T | PTB,THP,MDZ,PTZ | HAB | - (corticosteroid effective) |
| 20 | Normal | Bi-F | L-FP | R>L insula, cingulate | PTB,THP,MDZ,PTZ | HAB | – |
| 21 | MT, SEN | R-F | N.D | R-insula~BG, L-F, P | PTB | HAB | – |
| 22 | L-TPO FCD | L-PC | L-TPO | L-TPO | RIS,PTB | HAB | – |
| 23 | Normal | L-T/L-P (MEG) | N.D | L-O, L>R hippocampus | – | HAB | EcoG L-O |
| 24 | Normal | Bi-F-Diffuse | L-hemisphere | L-FT | DZP | HAB | – |
| 25 | MT | L-F, R-F multi | N.D | R-F, L-F, cingulate | PTB | HAB | – |
| 26 | L-HME, R-TO FCD | R-TO spike | L-FTP | L-deep WM, R-OT | THP,MDZ | HAB | – |
| 27 | Normal | L-insula | Normal | No specific uptake | – | HAB | – |
MRI magnetic resonance imaging, EEG electroencephalogram, MEG magnetoencephalography, FDC fludeoxyglucose F18, PET positron emission tomography, TESP translocator protein 18 kDa, R right, SNP single-nucleotide polymorphisms, L left, P posterior, T temporal, O occipital, MT multiple tubers, HME hemimegalencephaly, FCD focal cortical dysplasias, Bi bilateral, BG basal ganglia, WM white matter, CSWS continuous spikes and waves during sleep, PTB Pentobarbital, THP Thiopental, MDZ midazolam, LMP Levomepromazine, RIS Risperidone, TRF Triclofos, PTZ Pentazocine, DZP diazepam, HAB high-affinity binders.