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. 2021 Jan 7;19:27. doi: 10.1186/s12967-020-02638-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Development and validation of the tumor-infiltrating immune cell signature. a Univariate survival analysis identified survival-associated TIICs in patients with KRAS mutation based on training set. b Univariate survival analysis identified survival-associated TIICs in patients with KRAS mutation based on validation set. c Kaplan–Meier curves for patients with high- and low TIICs score in the training set. d Kaplan–Meier curves for patients with high- and low TIICs score in the validation set. e ROC curves for measuring the predictive value of the TIICs score in the training set and validation set