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. 2021 Jan 6;9:9. doi: 10.1186/s40478-020-01111-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Wide-spread brain volume changes and functional connectivity changes in R514G-FUS mice. a Brain structural changes between R514G and the control detected by tensor-based morphometry (p < 0.01, threshold-free cluster enhancement corrected). Wide-spread atrophy (cold color) can be found in the motor, insular, medial prefrontal, piriform, somatosensory and visual cortices and amygdala. Localized brain volume increase (hot color) can be seen mostly in subcortical areas, including ventral pallidum, lateral hypothalamus. Hippocampal CA3, medial geniculate nucleus and paraflocculus. N = 5 per genotype. b Functional connectivity measured by resting-state fMRI. (C) Connectivity matrix of resting-state functional connectivity change between R514G and the control (p < 0.001 uncorrected). Significant connectivity enhancement was seen between the left hippocampal CA2/3 and left visual cortex, and between the right hippocampal CA2/3 and the left diagonal band (n = 4 for non-transgenic, n = 5 for R514G-FUS mice)