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. 2021 Jan 6;9:9. doi: 10.1186/s40478-020-01111-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Reduction of long-term potentiation and spine density in the hippocampus of R514G mice. a, b LTP measurement of 6- and 12-month-old non-transgenic littermate control and R514G-FUS mice. fEPSPs were recorded in stratum radiatum (dendritic area) of the CA1 region following the stimulation of the Schaffer collateral pathway. LTP were induced with 4 tetanus stimulation delivered at 20-s intervals, each at 100 Hz for 1 s. Both 6- (a) and 12 months old (b) R514G-FUS mice showed reduced LTP when compared with their littermate controls. 6-month time-point: non-transgenic mice, n = 6; R514G-FUS mice n = 5. 12-month time-point: non-transgenic mice, n = 9; R514G-FUS mice n = 9. c Representative dendrite images of 6 month and 12 month old non-transgenic littermate control and R514G-FUS mice. Scale bar is 10 μm. d Quantification of spine density in 6 months and 12 months old non-transgenic littermate control and R514G-FUS mice. Spine density was reduced in the 6 and 12 months old R514G-FUS mice. Data are expressed as mean ± SEM; asterisks indicate significant differences between groups, n = 3 per genotype per time-point (*p < 0.05; unpaired t-test)