Table 5.

Time and events of work package IV

		Screening	Work package IV
			Day −5	Day 0	Day 7
Enrolment	Informed consent	X
	In/exclusion criteria	X
	Objective examination	X
Safety outcomes	Standard blood samples			X
Primary outcome	GI symptom questionnaires	X		X
Secondary outcomes	MRI scan of brain and GI tract		X
	Continuous glucose monitoring
	Holter monitoring
	Sudomotor function			X
	Cardiovascular reflexes			X
	Inflammation markers			X
	Cardiac vagal tone			X
	Resting EEG			X
	QST			X
	GI transit
	Autonomic function questionnaire			X

EEG, electroencephalography; GI, gastrointestinal; QST, quantitative sensory testing.