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. 2020 Dec 17;7:617321. doi: 10.3389/fmed.2020.617321

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Copyright © 2020 Ma, Zhao, Zhang, Sun, Li, Lin, Sun and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolomics profiling analyses for 40 μg/ml ozone group vs. control group. (A) Score plots of the principal component (PC) distinguishing 40 μg/ml ozone group (n = 6) from control group (n = 6) based on their metabolomics pattern with PC-1 (46.0%) and PC-2 (13.9%) in ESI+ mode. (B) Score plots of the PC distinguishing 40 μg/ml ozone group from control group based on their metabolomics pattern with PC-1 (43.6%) and PC-2 (15.3%) in ESI- mode. (C,D) Volcano plot demonstrates metabolite changes in ESI (±) mode. Fold change (FC) on the x-axis and FDR-adjusted P-values on the y-axis. Black vertical and horizontal lines show the filtering criteria (FC = 1.0 and FDR corrected P-value < 0.05).