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. 2020 Dec 17;7:617321. doi: 10.3389/fmed.2020.617321

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Copyright © 2020 Ma, Zhao, Zhang, Sun, Li, Lin, Sun and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ozone causes DNA damage, PAPR-1 excessive activation, NAD+ depletion and decline of ATP levels of SCNs. ABT-888 inhibits the NAD+ and ATP declines by inhibiting PARP1 excessive activation. (A–D) SCNs are treated with ozone (30 and 40 μg/ml for 60 min) in the absence or presence of ABT-888. The levels of PARP1, PAR, and γH2AX are measured and quantified by western blot. (E,F) Ozone exposure decreases the levels of NAD+ and ATP, which are prevented by ABT-888 pretreatment. Data are expressed as Mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, compared with the control without ABT-888 pretreatment; ^##P < 0.01, compared with control with 40 μg/ml ozone without ABT-888.