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. 2021 Jan 6;19:6. doi: 10.1186/s12967-020-02663-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The protein–protein interactions for the differentially expressed proteins in ApoE^−/−/LDLR^−/− mice (vs. WT) that were analysed using STRING 11 software. In the network analysis the differentially expressed proteins were presented as nodes, whereas edges represent predicted protein–protein associations. Using the protein interaction network analysis tool (STRING database), seven networks of the associated proteins were found among the differentially expressed proteins that were depicted by relevant colours. These included proteins mainly involved in: (1) acute phase response and/or being a constituent of lipoprotein particles (olive), (2) coagulation cascade (red), (3) alternative complement pathway (mint), (4) existing as inhibitors of serine proteases (light blue), (5) participating in adhesion of leukocytes to endothelial cells/renin-angiotensin system over-activation or modulation of oxidative stress (turquoise), (6) modulation of extracellular interactions/extracellular matrix re-organization (salmon), and (7) others – the disconnected node in the network represented by creatine kinase (hidden in the plot)