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Significantly altered metabolites in response to atherogenic dyslipidaemia in ApoE−/−/LDLR−/− mice. Plasma concentration of substrates for NOSs (L-Arg, H-Arg) and Arg precursors (L-Cit, L-Orn) (a), methylated Arg derivatives (NMMA, SDMA, ADMA) as well as L-Arg/ADMA ratio (b), L-Met, Hcy (c) and other metabolites significantly changed in response to dyslipidaemia (d) in ApoE−/−/LDLR−/− (n = 7) and WT (n = 9) mice. Data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. WT
