Table 1.
Patients’ and tumor characteristics
| Patient | Age (years) | Sex | Tumor site | Tumor location | WHO grade | Histologic features | Mutations and allele frequency (%) |
|---|---|---|---|---|---|---|---|
| MM#1 | 71 | F | Site-A | Infratentorial (L) | 1 | Transitional | AKT1 p.E17K (33%) |
| Site-B | Petroclival (L) | 1 | Meningothelial | TRAF7 p.K615N (29%) | |||
| MM#2 | 43 | F | Site-A | Convexity (R) | 1 | Microcystic | NF1 p.F384L (5%) |
| Site-B | Anterior SB (L) | 1 | Meningothelial/transitional | NF2 p.A325fs (37%) | |||
| MM#3 | 62 | M | Site-A | Convexity (R) | 2 | Atypical | NF2 p.E541* (32%) |
| Site-B | Petrosal (R) | 1 | Fibrous | None | |||
| MM#4 | 70 | F | Site-A | Sphenoid wing (R) | 1 | Transitional | PIK3CA p.H1047R (36%) |
| Site-B | Pineal region (M) | 1 | Meningothelial | AKT1 p.E17K (36%) | |||
| MM#5 | 49 | F | Site-A | Foramen magnum (M) | 1 | Meningothelial | POLR2A p.H439del (26%) |
| Site-B | Olfactory groove | 1 | Meningothelial | SMO p.L412F (40%) | |||
| MM#6 | 53 | F | Site-A | Sphenoid wing (R) | 1 | Transitional | PIK3CA p.H1047R (35%), TRAF7 p.S537F (38%) |
| Site-B | Planum spenoidale (M) | 1 | Mixed fibrous/meningothelial | PIK3CA p.E545G (30%) | |||
| Site-C | Convexity (L) | 1 | Fibrous | PIK3CA p.H1047R (38%) | |||
| MM#7 | 75 | F | Site-A | Petroclival (L) | 2 | Chordoid | AKT1 p.E17K (31%) |
| Site-B | Foramen magnum (M) | 2 | Transitional | TRAF7 p.R641H (33%) | |||
| MM#8 | 54 | F | Site-A | Convexity (L) | 1 | Meningothelial | TRAF7 p.Q38E (35%) |
| Site-B | Convexity (R) | 1 | Secretory | TRAF7 p.N520S (41%), KLF4 p.K409Q (40%) |
R right, L left, M midline