Table 1.

Top 10 GO terms (biological process and molecular function) and involved proteins by DAVID

GO ID	Term	P value	Involved proteins	Fold Enrichment
Biological process
GO:0060333	Interferon-gamma-mediated signaling pathway	1.45 × 10–4	HLA-DRB1, HLA-C, HLA-B, HLA-DRA, GBP1	18.48
GO:0098532	Histone H3-K27 trimethylation	2.06 × 10−4	HIST1H1E, HIST1H1D, HIST1H1C	131.19
GO:0016584	Nucleosome positioning	3.82 × 10−4	HIST1H1E, HIST1H1D, HIST1H1C	98.39
GO:0006334	Nucleosome assembly	1.03 × 10−3	H1F0, HIST1H1E, HMGB2, HIST1H1D, IST1H1C	11.02
GO:0019882	Antigen processing and presentation	1.14 × 10−3	HLA-DRB1, HLA-C, HLA-B, HLA-DRA	19.09
GO:0080182	Histone H3-K4 trimethylation	1.41 × 10−3	HIST1H1E, HIST1H1D, HIST1H1C	52.48
GO:0002437	Inflammatory response to antigenic stimulus	1.41 × 10−3	HMGB1, HMGB2, HLA-DRB1	52.48
GO:0006309	Apoptotic DNA fragmentation	1.41 × 10−3	H1F0, HMGB1, HMGB2	52.48
GO:0060337	Type I interferon signaling pathway	1.78 × 10−3	IFIT1, HLA-C, HLA-B, ISG20	16.40
GO:0051607	Defense response to virus	3.41 × 10−3	AZU1, IFIT1, DEFA3, ISG20, GBP1	7.96
Molecular function
GO:0032395	MHC class II receptor activity	1.98 × 10−5	KRT17, HLA-DRB1, HLA-C, HLA-DRA	72.61
GO:0042605	Peptide antigen binding	1.38 × 10−4	HLA-DRB1, HLA-C, HLA-B, HLA-DRA	38.90
GO:0005198	Structural molecule activity	2.62 × 10−3	KRT6C, PGM5, KRT17, FLG, SPRR1B, KRT1, SPRR3	7.72
GO:0000400	Four-way junction DNA binding	1.14 × 10−3	HMGB1, MSH6, HMGB2	58.34
GO:0031490	Chromatin DNA binding	1.20 × 10−3	H1F0, HIST1H1E, HIST1H1D, HIST1H1C	18.78
GO:0003684	Damaged DNA binding	1.53 × 10−3	HMGB1, MSH6, HMGB2, MSH5	17.29
GO:0046977	TAP binding	1.08 × 10−2	HLA-C, HLA-B	181.52
GO:097100	Supercoiled DNA binding	1.44 × 10−2	HMGB1, HMGB2	136.14
GO:0044822	Poly(A) RNA binding	1.94 × 10−2	H1F0, HMGB1, HIST1H1E, HMGB2, HIST1H1D, HIST1H1C, TRA2B, RPL26, TMSB4X, MANF	2.41
GO:0003725	Double-stranded RNA binding	2.05 × 10−2	HMGB1, YRDC, TUBB4B	13.39