Fig. 1.

Pedigree and clinical features of the two cases with familial progressive hyper- and hypopigmentation. a Pedigree of family 1. b–e Generalized hyper- and hypopigmentation with irregular patches was found at birth, and the patches (0.2–0.8 cm) progressed successively over her trunk, limbs, face and neck with age. f–i With age, the lesions increased in both size and number and became more noticeable and appeared on the trunk and limbs