Study period
	Enrolment	Allocation	Post-allocation				Close-out
TIMEPOINT**	− t1	0	T0	T1	T2	T3	tx
ENROLMENT:
Eligibility screen	X
Informed consent	X
Allocation		X
INTERVENTIONS:
[SEVO group]
[TIVA group]
ASSESSMENTS:
[age, sex, weight, height, BMI, ASA, NYHA, risk factors, preoperative medications]		X
[SEVO (%), gas flow (L/min), CPB flow (l/min/m2), BIS, Temperature (°C), MAP (mmHg), Ht, Hb, Ph, Lac, Glic, Na, K]			X	X	X	X
[PMN-elastase, IL-1β, IL-8, TGFβ, IL-6, TNFα, IL-10]							X
[Postoperative complications]							X

SEVO sevoflurane, TIVA total intravenous anesthesia, BMI body mass index, ASA American Society Of Anesthesiology (Physical State), NYHA New York Heart Association (Functional Class), Cpb cardiopulmonary bypass, BIS bispectral index, MAP mean arterial pressure, Ht hematocrit, Hb hemoglobin, Ph hydrogen potential, Lac lactate, Glic blood glucose, Na sodium, K potassium, PMN polymorphonuclear, IL interleukin, TGF transforming growth factor, TNF tumor necrosis factor