Table 3.
Clinical Characteristics and Patient Reported Outcome Measures Based on The Presence of Suicidal Ideation Among Adolescents with Juvenile Fibromyalgia Syndrome (N = 31)
| Variables | SI (n = 8) | No SI (n = 23) | p-value |
|---|---|---|---|
| Clinical Characteristics [median (IQR)] | |||
| Pain Duration (months) | 10 (5–24) | 24 (10–36) | 0.22 |
| Pain VAS (Visual Analog Scale) | 64 (60–75) | 54 (26–67) | 0.04* |
| Widespread Pain Index (WPI) | 12 (9–13) | 11 (9–14) | 0.80 |
| Symptom Severity Score (SSS) | 8 (7–10) | 8 (7–9) | 1.00 |
| Patient Reported Outcome Measures (PROs) [median (IQR)] | |||
| Functional Disability Inventory (FDI) (0–60) | 25 (16.5–31) | 20 (15–31) | 0.46 |
| PROMIS Global Health 7 (PGH-7) | 34 (28–40) | 39 (34–42) | 0.13 |
| 14-item Resilience Scale (14–98) | 58 (43–69) | 74 (67–81) | 0.02* |
| CDI-2 (Depression) | 74 (63–83) | 55 (51–67) | 0.02* |
| MASC-2 (Anxiety) | 83 (63–89) | 63 (50–70) | 0.01* |
| PedsQL Total Multidimensional Fatigue Scale (MFS) (0–100) | 37 (32–43) | 39 (28–56) | 0.80 |
| MFS General Fatigue | 29 (21–38) | 42 (25–54) | 0.21 |
| MFS Sleep | 31 (25–52) | 42 (29–54) | 0.39 |
| MFS Cognitive | 42 (40–63) | 38 (25–71) | 0.59 |
| BRIEF-2 Global Executive Composite (GEC) T Score | 57 (51–69) | 58 (49–71) | 1.00 |
Legend. *<0.05 = Significant p-value. IQR = interquartile range. Differences in characteristics were assessed using Wilcoxon Rank Sum test for continuous variables and Fisher’s Exact test for categorical variables. Pain VAS (visual analog scale) range from 0 to 100 with higher scores indicating more pain. SS scores total between 0 and 12 with higher scores indicating greater severity. WPI score ranges from 0 to 19 with higher values indicating greater involvement of different anatomical regions where the child has experienced pain over the past 7 days. Greater FDI scores indicate more functional disability. 14-item Resilience Scale - greater scores indicate greater resilience (ranging from 14 to 98). The Children’s Depression Inventory, 2nd Edition (CDI-2) is an assessment of depressive symptoms in children and adolescents ages 7–17 years, where T-scores ≥65 identify potentially clinically depressed individuals. The Multidimensional Anxiety Scale for Children, 2nd Edition (MASC-2) is a standardized, 50-item questionnaire assessing anxiety symptoms in adolescents where T-scores ≥60 indicate increased likelihood of at least one anxiety disorder in the subject. The Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL MFS) assesses 3 dimensions: general, sleep/rest, and cognitive fatigue. Scores ranges from 0 to 100 where higher scores indicate less symptoms/problems in a dimension. Behavior Rating Inventory of Executive Function-2 (BRIEF-2) is a standardized rating scale used to assess children’s executive functions in home and school environments where T scores from 60 to 64 are considered mildly elevated, and T scores from 65 to 69 are considered potentially clinically elevated