Table 1.
Baseline characteristics and comparison of PET results of patients with positive vs negative splenic switch off
| All patients n = 64 |
SSO present n = 46 (72%) |
SSO absent n = 18 (28%) |
p-Value | |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Mean age (years) | 51 ± 20 | 51.4 ± 18 | 49.2 ±24 | 0.69 |
| Male gender | 52 (81) | 37 (80) | 15 (83) | 0.30 |
| Weight (kg) | 80 ± 11 | 81 ± 10 | 75 ± 12 | 0.047 |
| Height (cm) | 175 ± 8 | 175 ± 8 | 176 (± 8 | 0.65 |
| Body mass index(kg/m2) | 26 ± 3 | 27 ± 3 | 24 ± 3 | 0.006 |
| Risk factors | ||||
| Diabetes mellitus | 5 (7.8) | 5 (11) | 0 (0) | 0.145 |
| Dyslipidaemia | 27 (42) | 21 (46) | 6 (34) | 0.37 |
| Hypertension | 25 (39) | 20 (43) | 5 (28) | 0.247 |
| Family history | 16 (25) | 12 (26) | 4 (23) | 0.748 |
| Smoking | 21 (33) | 17 (37) | 4 (23) | 0.259 |
| Medication | ||||
| Aspirin | 24 (38) | 17 (37) | 7(39) | 0.886 |
| Betablocker | 18 (28) | 15 (33) | 3 (17) | 0.202 |
| ACE inhibitor | 24 (38) | 18 (39) | 6 (34) | 0.667 |
| Statin | 27 (42) | 19 (41) | 8 (45) | 0.819 |
| Medical history | ||||
| Myocardial infarction | 10 (16) | 7 (15) | 3 (17) | 0.886 |
| Stenting | 18 (28) | 13 (28) | 5 (28) | 0.969 |
| CABG | 7 (11) | 4 (9) | 3 (170) | 0.358 |
| 13N-ammonia PET | ||||
| Ischemia | 15 (23) | 9 (20) | 6 (34) | 0.242 |
| Scar | 33 (52) | 22 (48) | 11 (61) | 0.1 |
| Stress MBF (ml/min/g) | 2.12 ± 0.68 | 2.2 ± 0.66 | 1.93 ± 0.72 | 0.23 |
| Rest MBF (ml/min/g) | 0.78 ± 0.26 | 0.77 ± 0.27 | 0.81 ± 0.24 | 0.65 |
| MFR | 2.91 (± 1) | 3.07 ± 1.03 | 2.48 ± 0.96 | 0.038 |
Values given are average ± standard deviations or absolute numbers and percentages (in brackets)
ACE angiotensin converting enzyme, CABG coronary artery bypass graft, CAD coronary artery disease, MBF myocardial blood flow, MFR myocardial flow reserve. SSO splenic switch-off