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. 2021 Jan 6;21:21. doi: 10.1186/s12935-020-01723-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Ferrichrome reduced the progression of colorectal cancer cells derived from primary or metastatic lesions. An SRB assay revealed that the numbers of colorectal cancer cells (Caco2/bbe, HCT116, SW-480 and HT29 cells, SK-CO-1 and SW-620 cells) were significantly lower in the ferrichrome groups than in the control group (n = 6) (a). The tumor volume and weight b in mice transplanted with SW620 cells were significantly decreased by the intraperitoneal injection of 5 mg/kg of ferrichrome without a decrease in the body weight c (0 mg/kg; n = 7, 5 mg/kg; n = 6). The tumor volume and weight d of mice transplanted with HCT116 cells were significantly decreased by the intraperitoneal injection of 5 mg/kg of ferrichrome (0 mg/kg; n = 5, 5 mg/kg; n = 6). The proportion of TUNEL-positive organoids e was significantly increased in the ferrichrome group compared to the control group. *p < 0.05 by a two-way ANOVA followed by Ryan’s post hoc test (A, B, D). *p < 0.05 by Student’s t-test (c, e). The error bars show the standard deviation (S.D.)