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. 2021 Jan 6;21:21. doi: 10.1186/s12935-020-01723-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Ferrichrome exerted anti-tumor effects but not the anti-inflammatory effects in an in vivo animal model. Ferrichrome (5 mg/kg) was administered via intraperitoneal injection to AOM-DSS carcinogenesis model mice for 69 days. The tumor size in the ferrichrome-treated model mice was significantly reduced a without any marked change in the body weight (b). A Western blot analysis showed that the accumulation of cleaved caspase-3 and PARP was significantly higher in the ferrichrome-treated group than in the control group (c). However, 5 mg/kg of ferrichrome administered trans-anally did not improve the colon length d or the expression of inflammatory cytokines (TNFα, IL1β and IFNγ) e in a DSS-colitis model. *p < 0.05 by a one-way ANOVA followed by Ryan’s post hoc test (a). *p < 0.05 by Student’s t-test (b, d, e). The error bars show the standard deviation (S.D.)