Table 3.
BKM120 (μM) | PQR309 (μM) | URMC-099 (μM) | CI* in U-251 MG cells | CI in U-343 MG cells | ||
---|---|---|---|---|---|---|
BKM120 + URMC-099 | PQR309 + URMC-099 | BKM120 + URMC-099 | PQR309 + URMC-099 | |||
0.5 | 1 | 0.75 | 1.3989 ± 0.2163 | 1.5254 ± 0.3801 | 4.7114 ± 0.2524 | 1.1346 ± 0.0512 |
1 | 2 | 1.5 | 1.4334 ± 0.1484 | 1.4664 ± 0.2958 | 3.6418 ± 0.8218 | 1.9790 ± 0.0174 |
2 | 4 | 3 | 1.1565 ± 0.2646 | 0.8072 ± 0.0409 | 2.9486 ± 0.6378 | 1.7963 ± 0.2530 |
3 | 6 | 4.5 | 0.8357 ± 0.0579 | 0.6518 ± 0.0092 | 1.2952 ± 0.5308 | 0.8334 ± 0.1518 |
4 | 8 | 6 | 1.1241 ± 0.1438 | 1.0504 ± 0.1408 | 0.9371 ± 0.0928 | 0.8804 ± 0.0166 |
5 | 10 | 7.5 | 1.6589 ± 0.2057 | 1.8739 ± 0.1506 | 1.1621 ± 0.0186 | 1.1876 ± 0.0811 |
* Data were presented as mean ± S.E.M. CI < 0.9 indicates synergistic effects; CI > 1.1 indicates antagonistic effects; CI between 0.9 and 1.1 indicates additive effects