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. 2021 Jan 6;40:16. doi: 10.1186/s13046-020-01810-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Inhibition of exosome secretion enhances miR-375 inhibition proliferation and invasion of glioma in vivo. a. Bioluminescence imaging indicating tumour size over time. b. Luminescent signal intensity of glioma-bearing mice in two groups. c. Evaluation of animal survival carried out according to Kaplan–Meier analysis. d. IHC staining of CTGF, Ki-67, and MMP9 in GW4869 group and DMSO group samples. Quantification of CTGF, Ki-67, and MMP9 intensity in IHC staining. Scale bar for 20X (left) = 100 μm, and 40X (right) =50 μm. Data are presented as mean ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001. ns, not significant