Fig. 2.

DTI and NODDI metric changes from day 2 to day 14 post-concussion. Voxel-by-voxel statistical analysis results of Diffusion Tensor Imaging (FA = Fractional Anisotropy, MD = Mean Diffusivity, Dp = Parallel Diffusivity, Dr = Radial Diffusivity) and Neurite Orientation Dispersion and Density Imaging metrics (NDI = Neurite Density Index, ODI = Orientation Dispersion Index) and Tensor-based Morphometry with Jacobian Index (JI) of a CON day 2 (n = 9) versus sham (n = 14), b CON day 7 (n = 10) versus sham (n = 10), and c CON day 14 (n = 10) versus sham (n = 14). Statistical map thresholded at P value < 0.05 (two-tailed), unpaired two sample t test, implemented as permutation tested for the General Linear Model, corrected for multiple comparisons with mass-based FSL’s Threshold-free Cluster enhancement (TFCE). Statistical maps were overlaid on the averaged and registered DTI and NODDI metrics maps corresponding to the statistical maps (DTI and NODDI results) and structural template (TBM results). Corresponding grey scale map for each averaged DTI and NODDI metrics maps were provided; units for Dp, Dr, and MD were in mm/s². ACA = Anterior Cingulate Area, AM = Amygdala, AUD = Auditory Area, cc = corpus callosum, ec = external capsule, HP = Hippocampus, HYP = Hypothalamus, ic = internal capsule, INS = Insula, MB = Midbrain, PAL = Palladium, S1 = Primary Somatosensory Cortex, RSN = Retrosplenial Area, STR = Striatum, TH = Thalamus, VIS = Visual Area. Red anatomical orientation marker L = Left, R = Right. An enlarged view of the DTI and NODDI metrics and the identified regions of interest (ROIs) can be found in Additional file 3: Fig. S3