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. 2021 Jan 6;40:12. doi: 10.1186/s13046-020-01806-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — HIF-1α/CASC15/SOX4/β-catenin pathway is activated in a substantial subset of NSCLC patients and A549 xenograft tissues. a Representative ISH staining of CASC15 and IHC staining of HIF-1α, SOX4, and β-catenin in a tissue microarray consisting of 35 matched pairs of NSCLC and adjacent normal lung tissues. Scale bar: 200 μm. b Positive correlation between CASC15 expression and levels of HIF-1α, SOX4, and β-catenin in NSCLC and adjacent normal lung tissues. LncRNA expression was evaluated by qRT-PCR, and protein abundance was evaluated by Western blotting. c Representative ISH staining of CASC15 and IHC staining of HIF-1α, SOX4, and β-catenin in A549-shControl and A549-shCASC15 xenograft tissues. d A schematic model of HIF-1α/CASC15/SOX4/β-catenin signaling pathway activated in NSCLC