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In silico structural analysis of HEXB mutations: Leu254Ser and Cys551Tyr
| Structural analysis | Dimerization capability | ||||
|---|---|---|---|---|---|
| I-TASSER | SWISS-MODEL (QMEAN) | MutationTaster | SWISS-MODEL (QSQE) | COTH | |
| Leu254 | helix | template: 1o7a | – | – | yes |
| Ser254 | coil | −0.77 | helix loss (253–258) | 1 | yes |
| Cys551 | coil | template: 1o7a | – | – | yes |
| Tyr551 | coil | −0.67 | disulfide loss (551) | 1 | yes |
| Ser254-Tyr551 | – | – | – | – | yes |
QMEAN, the Qualitative Model Energy Analysis; QSQE, quaternary structure quality estimate
