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. 2021 Jan 6;18:10. doi: 10.1186/s12974-020-02054-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Detection of TH⁺ nerve fibers in the brains of APP/PS1 and WT mice. a Immunofluorescence detection of TH⁺ nerve fibers in different brain regions showed that in the b medial prefrontal cortex, c anterior cingulate, d DG, and e CA3, TH⁺ nerve fibers gradually decreased with aging. In 12-month-old APP/PS1 mice, TH⁺ area was significantly reduced compared with WT mice of the same age and 3-month-old APP/PS1 mice. TH⁺ area in the brain slices of 3-month-old and 12-month-old APP/PS1 mice was significantly lower than that of WT mice of the same age. In DG, TH⁺ area of 12-month-old APP/PS1 mice was even significantly lower than that of 24-month-old WT mice. White box indicated region of interests used for the calculation of TH⁺ area. n = 6. ns, not significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, #P < 0.05 compared with other time points in the same group. ▲P < 0.05 compared with 12 m WT mice. ★P < 0.01 compared with 12 m APP/PS1 mice