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. 2021 Jan 6;21:14. doi: 10.1186/s12935-020-01698-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MiR-139-3p inhibitor reversed the inhibitory effect of shPCAT6 on BRD4 expression, and the viability and proliferation of PA cells. a, c The expressions of BRD4 in RC-4B/C and GH3 cells after ransfection were detected by RT-qPCR. GAPDH was used as an internal control. b, d The expressions of BRD4 in RC-4B/C and GH3 cells after transfection were detected by Western blot. GAPDH was used as an internal control. e, f The viability of RC-4B/C and GH3 cells after transfection was detected by CCK-8 assay. g–i The proliferation of RC-4B/C and GH3 cells after transfection was detected by colony formation assay. (^***P < 0.001, vs. MC + shNC; ^##P < 0.01, ^###P < 0.001, vs. IC + shNC; ^{^^^}P < 0.001, vs. I + shNC; ^▲P < 0.05, ^▲▲P < 0.01, ^▲▲▲P < 0.001, vs. shPCAT6 + IC). M: miR-139-3p mimic, MC mimic control, I miR-139-3p inhibitor, IC inhibitor control, shNC shRNA negative control