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. 2021 Jan 6;21:14. doi: 10.1186/s12935-020-01698-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — BRD4 was high-expressed in IPA and was targeted by miR-139-3p in PA cells. a The mRNAs that were possibly targeted by miR-139-3p were then predicted by miRDB, TargetScan, and TarBase v.8. b The putative binding site between miR-139-3p and SDCBP or BRD4 was predicted by Targetscan7.2. c, d The results of luciferase assay validated that miR-139-3p targeted SDCBP in PA cells RC-4B/C and GH3. e, f The results of luciferase assay validated that miR-139-3p targeted BRD4 in PA cells RC-4B/C and GH3. g The expressions of BRD4 in normal pituitary and IPA tissues were detected by RT-qPCR. GAPDH was used as an internal control. h, j The correlation between BRD4 expression and miR-139-3p expression in normal pituitary and IPA tissues was analyzed by Pearson correlation analysis. i, k The correlation between BRD4 expression and PCAT6 expression in normal pituitary and IPA tissues was analyzed by Pearson correlation analysis. (^{^}P < 0.05, ^{^^^}P < 0.001, vs. MC). IPA invasive pituitary adenomas, MC mimic control